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Drugs Used to Treat Motor Symptoms in Patients with Parkinson Disease Ergot-derived dopamine agonists such as cabergoline, bromocriptine (Parlodel), lisuride, and pergolide should not be used as first-line treatments because of the risk of serosal fibrosis and cardiac valvulopathies

Molecular mechanisms underlying the neuroprotective effects of ITC have also been studied in vitro

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Additionally, the reduced plasma levels of brain-derived neurotrophic factor (BDNF) observed in BIPN patients may be associated with BTZ-mediated inhibition of platelet aggregation and activation, which in turn leads to decreased BDNF release and consequently impairs its neuroregenerative effects on peripheral nerves (Nishiwaki et al., 2020)

Liu JY, Lee KF, Sze CW, Tong Y, Tang SCW, Ng TB, et al